Thermo Fisher Scientific CREB Monoclonal Antibody (LB9)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA1-083 detects CREB in human, monkey, rat, and mouse cells.
It has been successfully used in immunofluorescence, Western blot, immunoprecipitation, immunohistochemistry, and ELISA.
By Western blot, this antibody detects a ~43 kDa protein.
The immunogen is recombinant human CREB-A protein.

Target Information

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals such as neurotransmitters, hormones, membrane depolarization, and growth/neurotrophic factors.
Activation of CREB depends on phosphorylation at serine 133, mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1.
While CREB can bind DNA regardless of phosphorylation, only the phosphorylated form acts as an active transcription factor.
CREB binding protein (CBP) interacts with CREB at the serine 133 region and functions as a transcriptional coactivator.
CREB is involved in processes such as circadian rhythm regulation, adipocyte differentiation, and learning and memory.
In humans, the gene is located on chromosome 2q.
CREB dysfunction is associated with diseases including Alzheimer’s disease, histiocytoma, and soft tissue melanoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.