Thermo Fisher Scientific Human FGF-19 Recombinant Protein, PeproTech

Applications

Functional Assay (Functional)

• Assay-dependent

In vitro Assay (IV)

• Refer to 12 related publications

Miscellaneous PubMed (Misc)

• Refer to 1 related publication

Product Specifications

Product Specific Information

• Catalog No. 100-32-1MG is supplied as 2 × 500 µg (100-32-500UG).
• Recombinant Human FGF-19 is a 21.8 kDa protein containing 195 amino acid residues.
• Shipped at ambient temperature.
• For storage, handling, and reconstitution details, refer to the lot-specific Certificate of Analysis.

Target Information

FGF19 (Fibroblast Growth Factor 19) is a human protein encoded by the FGF19 gene, located on chromosome 11q13.3.
It belongs to the fibroblast growth factor family and contains a signal sequence with two conserved cysteine residues.
Expression is detected in fetal brain tissue but not in adult brain.

FGF19 plays a key role in hepatic protein and glycogen synthesis without inducing lipogenesis.
Its effects are independent of insulin or Akt kinase activity, acting instead through a MAP kinase signaling pathway that promotes protein translation and glycogen synthase activation.
The mouse ortholog, FGF15, shares ~50% amino acid identity and similar biological functions. Together, they are often referred to as FGF15/19.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.