Thermo Fisher Scientific KIR2D Monoclonal Antibody (NKVFS1)
인간 KIR2D 단백질을 인식하는 마우스 단클론 항체로, WB, Flow, ELISA, IP 등 다양한 응용에 사용 가능. NK 세포 활성화 및 억제 기능 연구에 적합. 비결합형 액상 형태로 1 mg/mL 농도, Protein G로 정제됨.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Flow Cytometry (Flow) | 1:50–1:100 | |
| ELISA | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NKVFS1 |
| Immunogen | Proprietary Immunogen |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2130393 |
Product Specific Information
Clone NKVFS1 recognizes the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1, and KIR2DS2 respectively) and also p50.3 (KIR2DS4).
This clone is reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Target Information
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.
The KIR genes are polymorphic and highly homologous, located in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
The KIR gene cluster content varies among haplotypes, though several framework genes are common to all.
KIR proteins are classified by:
- Number of extracellular immunoglobulin domains (2D or 3D)
- Cytoplasmic domain length (L: long, S: short)
KIRs with long cytoplasmic domains transduce inhibitory signals via ITIM motifs, while short forms associate with TYRO protein tyrosine kinase binding protein to transduce activating signals.
Ligands for several KIR proteins are subsets of HLA class I molecules, indicating their role in immune regulation.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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