Thermo Fisher Scientific MUC1 Recombinant Rabbit Monoclonal Antibody (SN06-80)
Thermo Fisher Scientific의 MUC1 Recombinant Rabbit Monoclonal Antibody (SN06-80)은 인간 MUC1 단백질을 인식하는 고특이성 항체로, WB, IHC, ICC/IF, Flow Cytometry 등에 적합합니다. 재조합 기술로 생산되어 로트 간 일관성이 높고, 민감도 및 특이성이 우수합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (IHC) | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 |
| Flow Cytometry (Flow) | 1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN06-80 |
| Immunogen | Synthetic peptide within Human MUC1 aa 1,206–1,255 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809551 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to large rabbit immune repertoire
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain, undergoing proteolytic processing and extensive O-linked glycosylation.
MUC1 is highly polymorphic, with alleles encoding different repeat numbers (30–90), resulting in variable molecular weights.
It is abundantly expressed in >90% of breast carcinomas and metastases.
Overexpression, aberrant intracellular localization, and altered glycosylation are associated with carcinomas.
Multiple alternatively spliced transcript variants exist, with several full-length isoforms identified.
Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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