Thermo Fisher Scientific Caspr2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
CNKDVGAFFE EGMWLRYNFQ APATNARDSS SRVDNAPDQQ NSHPDLAQEE IRFSFSTTKA PCILLYISSF TTDFLAVLVK PTGSLQIRYN LGGTREPYNI DVDHRNMANG QPHSVNITRH EKTIFLKLDH YPSVSYHLPS SS

Target Information

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein contains epidermal growth factor repeats, laminin G domains, F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains, and a putative PDZ binding site.
It is localized at the juxtaparanodes of myelinated axons and mediates interactions between neurons and glia during nervous system development. It is also involved in localization of potassium channels within differentiating axons.
This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by FOXP2, a transcription factor related to speech and language development.
This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD, and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.