Thermo Fisher Scientific IkB epsilon Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: [References not provided]

Product Specifications

Product Specific Information

Immunogen sequence:
PEPGRGTSHS LDLQLQNWQG LACLHIATLQ KNQPLMELLL RNGADIDVQE GTSGKTALHL AVETQERGLV QFLLQAGAQV DARMLNGCTP LHLAAGRGLM GISSTLCKAG ADSLLRNVED ETPQDLTEES LVLLPFDDLK I

Target Information

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex.
The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm.
Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex.
Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5′ GGGRNNYYCC 3′ or 5′ HGGARNYYCC 3′ (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6, MIM 601512), AP1 (JUN, MIM 165160), and NFAT (see NFATC1, MIM 600489).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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