Thermo Fisher Scientific Arginase 1 Recombinant Rabbit Monoclonal Antibody (PD00-05)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: Human liver tissue lysates, human liver tissue
• Predicted band size: 35 kDa
• Subcellular Location: Cytoplasm, Cytoplasmic granule

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, the final step in the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts. By degrading arginine, Arginase 1 limits substrate availability for nitric oxide synthase, reducing nitric oxide production.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, expression is reported in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 is often expressed in myeloid cells infiltrating tumors and is typically found in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.