Thermo Fisher Scientific Factor XIII A Recombinant Rabbit Monoclonal Antibody (PD00-08)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

• Positive control: Human placenta tissue lysates, human lymph nodes tissue, human placenta tissue
• Predicted band size: 83 kDa
• Subcellular Location: Secreted, Cytoplasm

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of two A subunits identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme, factor XIIIa, identical to platelet factor XIII. This enzyme acts as a transglutaminase, catalyzing gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules to stabilize the clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin. Factor XIII deficiency may cause lifelong bleeding tendencies, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.