Thermo Fisher Scientific PYCARD Recombinant Rabbit Monoclonal Antibody (SN07-10)
PYCARD 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow Cytometry에 적합합니다. 높은 특이성과 재현성을 제공하며, Protein A 정제, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:400 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN07-10 |
| Immunogen | Synthetic peptide within Human TMS1 aa 121–170 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809594 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to rabbit immune repertoire
Target Information
PYCARD functions as a key mediator in apoptosis and inflammation. It promotes caspase-mediated apoptosis, particularly involving caspase-8 and caspase-9, and participates in mitochondrial apoptotic pathways.
It is crucial in macrophage pyroptosis and inflammasome assembly, activating caspase-1 and processing proinflammatory cytokines.
PYCARD acts as an adapter in multiple inflammasomes (NLRP2, NLRP3, AIM2, IFI16) and modulates NF-κB signaling.
Isoforms may regulate inflammasome activity and cytokine maturation.
In adaptive immunity, it supports dendritic cell maturation and T-cell activation, and may influence cytoskeletal rearrangement and transcriptional activation of cytokines and chemokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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