Thermo Fisher Scientific BPI Recombinant Rabbit Monoclonal Antibody (SN06-63)
Recombinant rabbit monoclonal antibody against Human BPI (aa 131-180). Validated for Western blot and Flow cytometry. Offers high specificity, lot-to-lot consistency, and animal-free formulation. Suitable for research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN06-63 |
| Immunogen | Synthetic peptide within Human BPI aa 131–180 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809591 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
BPI (Bactericidal/Permeability-Increasing protein) is a 55 kDa antimicrobial protein located in the primary granules of human neutrophils and detected on neutrophil surfaces, small intestinal, and oral epithelial cells.
It binds with high affinity to the lipid A region of lipopolysaccharides (LPS) in gram-negative bacterial membranes, leading to:
- Cytotoxicity via membrane damage
- Neutralization of bacterial LPS
- Opsonization to enhance phagocytosis
BPI may play a role in airway disease development triggered by LPS, as airway epithelial cells express BPI constitutively. A recombinant fragment, rBPI21 (21 kDa), has shown protective effects against pneumococcal infections by binding to pneumolysin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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