Thermo Fisher Scientific PPP2R2B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  KIRWLPQQNA AYFLLSTNDK TVKLWKVSER DKRPEGYNLK DEEGRLRDPA TITTLRVPVL RPMDLMVEAT PRRVFANAHT YHINSISVNS DYETYMSADD L
• Positive Samples: U-87MG, SH-SY5Y, HepG2, Mouse brain, Mouse lung, Rat brain
• Cellular Location: Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Cytoskeleton

Target Information

The PPP2R2B gene encodes a beta isoform of the regulatory subunit B55 of protein phosphatase 2 (PP2A), a major Ser/Thr phosphatase involved in negative regulation of cell growth and division. PP2A consists of a catalytic subunit and a constant regulatory subunit forming a heteromeric core enzyme, which associates with various regulatory subunits to modulate substrate selectivity and catalytic activity.
Defects in PPP2R2B cause autosomal dominant spinocerebellar ataxia 12 (SCA12), characterized by cerebellar degeneration and impaired motor coordination. Multiple alternatively spliced variants exist, some containing expanded CAG trinucleotide repeats (66–78 copies) in SCA12 cases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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