Thermo Fisher Scientific PPP2R2B Polyclonal Antibody
PPP2R2B 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 ELISA에 적합하며, 고순도 Affinity Chromatography로 정제되었습니다. 세포 성장 조절 연구 및 신경계 질환 관련 단백질 분석에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 160–260 of human PP2A-B55β/PR55β/PPP2R2B (UniProt ID: Q00005-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804525 |
Product Specific Information
- Immunogen sequence:
KIRWLPQQNA AYFLLSTNDK TVKLWKVSER DKRPEGYNLK DEEGRLRDPA TITTLRVPVL RPMDLMVEAT PRRVFANAHT YHINSISVNS DYETYMSADD L - Positive Samples: U-87MG, SH-SY5Y, HepG2, Mouse brain, Mouse lung, Rat brain
- Cellular Location: Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Cytoskeleton
Target Information
The PPP2R2B gene encodes a beta isoform of the regulatory subunit B55 of protein phosphatase 2 (PP2A), a major Ser/Thr phosphatase involved in negative regulation of cell growth and division. PP2A consists of a catalytic subunit and a constant regulatory subunit forming a heteromeric core enzyme, which associates with various regulatory subunits to modulate substrate selectivity and catalytic activity.
Defects in PPP2R2B cause autosomal dominant spinocerebellar ataxia 12 (SCA12), characterized by cerebellar degeneration and impaired motor coordination. Multiple alternatively spliced variants exist, some containing expanded CAG trinucleotide repeats (66–78 copies) in SCA12 cases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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