Thermo Fisher Scientific PPP2R2B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 160-260 of human PP2A-B55β/PR55β/PP2A-B55β/PR55β/PPP2R2B (NP_8580602) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PPP2R2B,uniProtId:Q00005-1,ncbiNodeId:9606,antigenRange:160-260,antigenLength:443,antigenImageFileName:PA5-87943_PPP2R2B_Q00005-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87943_PPP2R2B_Q00005-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.85 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804525

Product Specific Information

Immunogen sequence: KIRWLPQQNA AYFLLSTNDK TVKLWKVSER DKRPEGYNLK DEEGRLRDPA TITTLRVPVL RPMDLMVEAT PRRVFANAHT YHINSISVNS DYETYMSADD L; Positive Samples: U-87MG, SH-SY5Y, HepG2, Mouse brain, Mouse lung, Rat brain; Cellular Location: Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, cytoskeleton

Target Information

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5` UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.