Thermo Fisher Scientific RASGRP1 Polyclonal Antibody
RASGRP1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, ICC/IF, ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS/glycerol 버퍼 보존, 인체·마우스·랫트 반응성이 검증되었습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 598–797 of human RASGRP1 (NP_0057302) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804526 |
Product Specific Information
Immunogen sequence:
PVAPTENNTS VGPVSNLCSL GAKDLLHAPE EGPFTFPNGE AVEHGEESKD RTIMLMGVSS QKISLRLKRA VAHKATQTES QPWIGSEGPS GPFVLSSPRK TAQDTLYVLP SPTSPCPSPV LVRKRAFVKW ENKDSLIKSK EELRHLRLPT YQELEQEINT LKADNDALKI QLKYAQKKIE SLQLEKSNHV LAQMEQGDCS
Positive Samples: Jurkat, MCF7, A-549, U-251MG, SW480
Cellular Location: Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein, Cytosol
Target Information
RASGRP1 functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor that specifically activates Ras by exchanging bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cell/B-cell development, homeostasis, and differentiation by coupling antigen receptors to Ras. It also regulates NK cell cytotoxicity and cytokine production through ERK and JNK pathways, and functions in mast cell degranulation and cytokine secretion involved in allergic responses. RASGRP1 may also play a role in the differentiation of other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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