Thermo Fisher Scientific IkB zeta Polyclonal Antibody
Thermo Fisher Scientific의 IkB zeta Polyclonal Antibody는 Rat 시료에 반응하는 Rabbit IgG 폴리클로날 항체입니다. Western blot과 ELISA에 사용 가능하며, 핵 내 IkB-zeta 단백질 검출에 적합합니다. 고순도 Affinity Chromatography 정제 및 안정적 액상 형태로 제공됩니다.
- 카탈로그번호
- PA587941
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–220 of human NFKBIZ (NP_1136071) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.38 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804523 |
Product Specific Information
Immunogen sequence:
MIVDKLLDDS RGGEGLRDAA GGCGLMTSPL NLSYFYGASP PAAAPGACDA SCSVLGPSAP GSPGSDSSDF SSASSVSSCG AVESRSRGGA RAERQPVEPH MGVGRQQRGP FQGVRVKNSV KELLLHIRSH KQKASGQAVD DFKTQGVNIE QFRELKNTVS YSGKRKGPDS LSDGPACKRP ALLHSQFLTP PQTPTPGESM EDVHLNEPKQ ESSADLLQNI
Positive Samples: LO2, THP-1, Mouse kidney, Rat kidney
Cellular Location: Nucleus
Target Information
I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein highly homologous to the IkappaB family member Bcl-3.
Transcription of IkappaB-zeta is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly in T-lymphocytes, fibroblasts, and endothelial cells.
IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65, and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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