
Thermo Fisher Scientific MECP2 Polyclonal Antibody
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Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000
ELISA (ELISA)
1:500-1:1,000
Immunoprecipitation (IP)
50-100 µg/mL
ChIP assay (ChIP)
5 µg/1x10^6 cells
RNA Immunoprecipitation (RIP)
Assay-dependent
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Raised against the C-term of human MECP2. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
MECP2,
uniProtId:
P51608-1,
ncbiNodeId:
9606,
antigenRange:
486,
antigenLength:
486,
antigenImageFileName:
49-1029_MECP2_P51608-1_Rabbit.svg,
antigenImageFileNamePDP:
49-1029_MECP2_P51608-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.05% sodium azide, 0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
RRID
AB_2533879
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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