Thermo Fisher Scientific Robo3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: Robo3.

Target Information

The ROBO3 gene belongs to the Roundabout (ROBO) gene family, which controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are part of the immunoglobulin transmembrane receptor superfamily. SLIT proteins (1–3) are ligands for ROBO proteins, and SLIT/ROBO interactions regulate processes such as myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis, in addition to neurogenesis.

ROBO3 has an extracellular domain with five immunoglobulin-like loops, three fibronectin type III motifs, a transmembrane segment, and a cytoplasmic tail with conserved signaling motifs (CC0, CC2, CC3). Unlike other ROBO family members, ROBO3 lacks the CC1 motif. In mice, loss of Robo3 results in failure of commissural axons to cross the midline of the spinal cord and hindbrain. Mutations in ROBO3 cause horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by absence of horizontal gaze and progressive scoliosis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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