Thermo Fisher Scientific RYR2 Polyclonal Antibody
RYR2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC에 적합하며, 인간 시료에 반응. 합성 펩타이드(aa 1350-1400)를 면역원으로 사용. 동결건조 형태로 제공되며, 4°C 또는 -20°C에서 보관 권장.
- 카탈로그번호
- OSR00367W-100UL
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acids 1350–1400 of human Ryanodine receptor 2 (RYR2) conjugated to blue carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: RYR2.
Target Information
Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca²⁺ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop thought to be involved in interactions with RyR. Phosphorylation of the DHPR alpha1-subunit may also play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis. Cells lacking RyR also lack excitation-contraction coupling and exhibit a significant reduction in Ca²⁺ current density.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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