Thermo Fisher Scientific RYR2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity: RYR2.

Target Information

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca²⁺ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop thought to be involved in interactions with RyR. Phosphorylation of the DHPR alpha1-subunit may also play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis. Cells lacking RyR also lack excitation-contraction coupling and exhibit a significant reduction in Ca²⁺ current density.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.