Thermo Fisher Scientific MMP2 Polyclonal Antibody

Thermo Fisher Scientific MMP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

This affinity-purified antibody is directed against human MMP2. BLAST analysis suggests cross-reactivity with mouse, rat, bovine, and Oryctolagus cuniculus based on 100% homology with the immunizing sequence.

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a common activation mechanism and a conserved amino acid sequence in the metal-binding active site region, and are inhibited by tissue inhibitors of metalloproteinases (TIMPs).
MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains. MMP2 plays a key role in tissue remodeling and angiogenesis regulation.
Mutations in the MMP2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.