Thermo Fisher Scientific Phospho-PAX2 (Ser393) Polyclonal Antibody
PAX2 단백질의 Ser393 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC(P), ELISA 등에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide derived from the sequence surrounding the phosphorylated Ser393 residue of mouse and human Pax2 (paired box protein 2). Ser393 of the 415 amino acid mouse Pax2 isoform is equivalent to Ser394 of the 416 amino acid human Pax2 isoform, and to Ser371 of the 393 amino acid human Pax2 isoform. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533286 |
Target Information
The PAX genes are a family of transcription factors active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box, enabling them to regulate genetic programs.
Several Pax genes are associated with developmental mutations:
- PAX3: Waardenburg syndrome
- PAX6: Aniridia
- PAX2: Wilms tumor
During embryogenesis, PAX2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures derived from mesenchyme. PAX2 mRNA and protein levels decrease as the tubular epithelium matures. However, PAX2 expression persists in the undifferentiated epithelium of Wilms tumors, correlating with poorly differentiated epithelial cell proliferation.
The Wilms tumor suppressor protein WT1 coincides with the down-regulation of PAX2, suggesting WT1 directly represses PAX2 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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