Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser31) Polyclonal Antibody
Phospho-Tyrosine Hydroxylase (Ser31) 폴리클로널 항체로, 인간·마우스·랫트에 반응하며 WB, IHC, ICC/IF에 사용 가능. 합성 인산화 펩타이드 면역원 기반, 액상 형태로 -20°C 보관. 카테콜아민 합성 관련 연구에 적합.
- 카탈로그번호
- 369900
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser31) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 6 publications |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:300 | - |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho peptide derived from a region of the rat tyrosine hydroxylase (TH) protein surrounding the phosphorylated Ser31 residue |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 50% glycerol, 0.15M NaCl, 100 µg/mL BSA |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533288 |
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters — dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with its cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate enzymatic activity.
Human TH has four mRNA splice variants (hTH1–hTH4), identical in their catalytic domain but differing in their N-terminal regulatory domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology. Dysfunction of TH is associated with several neuropathogenic and cardiovascular diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, and dystonia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.