Thermo Fisher Scientific FGF23 (Fibroblast Growth Factor 23) Monoclonal Antibody (FGF23/4169)
인간 FGF23 단백질을 인식하는 mouse monoclonal antibody로, IHC(P), IHC(PFA), Peptide Array 등 다양한 응용에 적합. 고순도 Protein A/G 정제, PBS 버퍼에 안정화되어 연구용으로 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2 µg/mL
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FGF23/4169 |
| Immunogen | Recombinant fragment (around aa25–251) of human FGF23 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in various biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion.
FGF23 inhibits renal tubular phosphate transport. Mutations in this gene are associated with autosomal dominant hypophosphatemic rickets, an inherited phosphate wasting disorder. Abnormally high expression of FGF23 is observed in oncogenic hypophosphatemic osteomalacia, a disease caused by abnormal phosphate metabolism.
Additionally, mutations in FGF23 can cause familial tumoral calcinosis with hyperphosphatemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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