Thermo Fisher Scientific FGF23 (Fibroblast Growth Factor 23) Monoclonal Antibody (FGF23, 4168)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
• For staining of formalin-fixed tissues: heat tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in various biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. The product of this gene inhibits renal tubular phosphate transport.
Mutations in this gene are associated with autosomal dominant hypophosphatemic rickets and familial tumoral calcinosis with hyperphosphatemia. Abnormally high expression levels have been found in oncogenic hypophosphatemic osteomalacia, a disease caused by abnormal phosphate metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.