Thermo Fisher Scientific Phospho-STK17b (Ser11) Polyclonal Antibody
Phospho-STK17b (Ser11) 특이적 폴리클로날 항체로, 인간·마우스·래트 시료에서 WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체로 핵 내 STK17B 단백질 검출에 적합. 연구용으로만 사용.
- 카탈로그번호
- 630-350
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-STK17b (Ser11) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from N-terminus of human STK17b at phosphorylation site Serine 11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: MOLT4 cells
- Cellular location: Nucleus
Target Information
STK17B (also known as DRAK2) is a member of the serine/threonine kinase family related to death-associated protein kinase that triggers apoptosis. It plays a key role in T-cell survival and has therapeutic potential for autoimmune diseases. STK17B deficiency may affect autoimmune disease susceptibility without generalized immune suppression.
Protein kinases are central to signal transduction in response to external stimuli. Overexpression of ZIP kinase induces apoptotic morphology in NIH 3T3 cells. Sanjo et al. identified DRAK1 and DRAK2 (Death Receptor Associated Kinases), which share significant homology with ZIP kinase and DAP kinase involved in interferon-γ–induced apoptosis. Overexpression of DRAKs in NIH 3T3 cells leads to apoptosis, suggesting the C-terminal domain of DRAKs is critical for apoptosis induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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