Thermo Fisher Scientific STK17b Polyclonal Antibody
STK17b 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 내 핵에서 발현되는 STK17B 단백질 연구에 유용합니다.
- 카탈로그번호
- 630-360
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from N-terminus of human STK17b (DRAK2, UniProt ID: O94768-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: MOLT4 cells
- Cellular location: Nucleus
Target Information
STK17B (also known as DRAK2) is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis. STK17B plays a critical role in T-cell survival and has potential therapeutic relevance in autoimmune diseases.
Deficiency of STK17B can influence autoimmune disease susceptibility without general immune suppression.
Protein kinases are key regulators in signal transduction responding to various external stimuli.
Overexpression of DRAKs, including STK17B, in NIH 3T3 cells induces apoptosis, suggesting the C-terminal domain of DRAKs is essential for this process.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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