Thermo Fisher Scientific Connexin 31 Polyclonal Antibody

Thermo Fisher Scientific Connexin 31 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 0.125 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: MDWKKLQDLL SGVNQYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD
• Storage recommendations:
  • Short term: Store at 2–8°C up to 1 week
  • Long term: Store at -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology:
  Cow 79%, Dog 83%, Horse 83%, Human 83%, Mouse 100%, Pig 83%, Rabbit 79%, Rat 100%, Zebrafish 92%

Target Information

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family.
GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels.
Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV), an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis.
Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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