Thermo Fisher Scientific MPP5 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MPP5 N-terminal region. Validated for Western blot. High specificity and purity with affinity chromatography. Supplied as liquid, 0.5 mg/mL in PBS with sucrose and sodium azide. For research use only.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human MPP5 (aa 36–85) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2884274 |
Product Specific Information
Immunogen sequence:
AVDCPGDLGT RMMPIRRSAQ LERIRQQQED MRRRREEEGK KQELDLNSSM
- For short-term use, store at 2–8°C up to 1 week.
- For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 80%
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. This protein is essential for establishing and maintaining cell polarity in epithelial cells and neurons. It is part of the Par-3 complex that contributes to maintaining tight junctions in epithelial cells.
Mutations in MPP5 are linked to severe neurologic impairments, including global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is involved in early differentiation of multipotent progenitors and supports lineage-specific contributions, mainly in myeloid and lymphoid cells. MPP5 variants can disrupt normal cellular function, leading to developmental and functional abnormalities.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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