Thermo Fisher Scientific KIDINS220 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• Store reconstituted solution at 4°C for up to 1 week.
• For longer storage, aliquot and keep at -20°C.
• Avoid repeated freeze-thaw cycles.
• Centrifuge antibody preparations before use (10,000 × g, 5 min).

Peptide sequence: (C)PRHSNLS WQSQTRR
Homology: Mouse and human amino acid residues are identical.

Target Information

KIDINS220 encodes a transmembrane protein predominantly expressed in the nervous system. It regulates neuronal cell survival, differentiation, and synaptic plasticity. The protein interacts with membrane receptors, signaling molecules, and cytoskeletal components, functioning as a scaffold for neurotrophin and other intracellular signaling pathways. Abnormal expression is linked to neuropsychiatric and neurodegenerative disorders such as Alzheimer’s disease. Mutations can cause a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus, and obesity. Multiple transcript variants exist due to alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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