Thermo Fisher Scientific PLXNA3 (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and store at -20°C.
• Avoid repeated freeze-thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g for 5 min).

Peptide sequence: (C)KVRVDGSQDAQLYE
Homology: Rat – identical; Human – 12/14 amino acids identical.

Target Information

PLXNA3 acts as a coreceptor for SEMA3A and SEMA3F, essential for class 3 semaphorin signaling and cytoskeletal remodeling. It plays a key role in axon guidance during nervous system development, regulates sympathetic neuron migration, and is required for normal dendritic spine morphology in pyramidal neurons. It may also influence semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex of neuropilin and plexin, where the plexin domain modulates affinity and triggers downstream signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.