Thermo Fisher Scientific COL1A2 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
IKVYCDFSTG ETCIRAQPEN IPAKNWYRSS KDKKHVWLGE TINAGSQFEY NVEGVTSKEM ATQLAFMRLL ANYAS

Antigen sequence identity:

• Mouse: 83%
• Rat: 81%

Target Information

The COL1A2 gene encodes the pro-alpha2 chain of type I collagen, which forms a triple helix composed of two alpha1 chains and one alpha2 chain. Type I collagen is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in this gene are associated with:

• Osteogenesis imperfecta types I–IV
• Ehlers-Danlos syndrome type VIIB
• Recessive Ehlers-Danlos syndrome Classical type
• Idiopathic osteoporosis
• Atypical Marfan syndrome

Symptoms linked to COL1A2 mutations are generally less severe than those caused by COL1A1 mutations, reflecting the distinct structural role of alpha2 chains in matrix integrity. Three transcripts have been identified for this gene, resulting from alternate polyadenylation signals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.