Thermo Fisher Scientific COL1A2 Polyclonal Antibody
COL1A2 단백질을 인식하는 토끼 폴리클로날 항체로, 인간 시료에 반응합니다. 면역세포염색(ICC/IF)에 적합하며 고순도 친화 크로마토그래피로 정제되었습니다. PBS와 글리세롤 기반 용액 상태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
- 카탈로그번호
- PA5144958
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 1099–1135). Recombinant protein control fragment: Product # RP-110208 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092087 |
Product Specific Information
- Immunogen sequence: GPPGVSGGGY DFGYDGDFYR ADQPRSAPSL RPKDYEV
- Antigen sequence identity: Mouse 92%; Rat 92%
Target Information
The COL1A2 gene encodes the pro-alpha2 chain of type I collagen, which forms a triple helix with two alpha1 chains and one alpha2 chain. Type I collagen is a fibril-forming collagen found in most connective tissues, including bone, cornea, dermis, and tendon.
Mutations in this gene are associated with:
- Osteogenesis imperfecta types I–IV
- Ehlers-Danlos syndrome type VIIB and recessive classical type
- Idiopathic osteoporosis
- Atypical Marfan syndrome
Symptoms linked to COL1A2 mutations are generally less severe than those caused by COL1A1 mutations, reflecting the distinct structural role of the alpha2 chain in extracellular matrix integrity.
Three transcript variants have been identified, resulting from alternative polyadenylation signals.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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