Thermo Fisher Scientific ATR Polyclonal Antibody
Human ATR 단백질에 특이적인 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 4 mg/mL 농도의 액상 형태이며, PBS와 0.05% sodium azide 포함. DNA 손상 반응 및 세포 주기 조절 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 17 publications |
| Immunoprecipitation (IP) | Assay-dependent | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein containing residues 400–460 of the human ATR protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_325822 |
Product Specific Information
PA1-450 detects ATR (Ataxia Telangiectasia Mutated (ATM) and Rad3-related protein) from human cells.
PA1-450 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures.
By Western blot, this antibody detects an ~305 kDa protein representing ATR in lysate from UV-irradiated K562 cells.
The PA1-450 antigen is a fusion protein corresponding to amino acid residues 400–460 from human ATR.
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress.
It can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, promoting DNA repair, recombination, and apoptosis.
This protein is also important for fragile site stability and centrosome duplication.
Defects in this gene are a cause of Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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