Thermo Fisher Scientific BCAS1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide: D(532) T N S L Q N G D K L Q K R P E K R Q(550) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BCAS1,uniProtId:O75363-1,ncbiNodeId:9606,antigenRange:532-550,antigenLength:584,antigenImageFileName:PA1-4398_BCAS1_O75363-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4398_BCAS1_O75363-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2258969

Product Specific Information

PA1-4398 detects NABC1 in human samples.

PA1-4398 has been successfully used in Western blotting procedures. By Western blot, this antibody detects a ~60 kDa protein representing NABC1 in MCF-7 cell lysates. NABC1 can form dimers, which are readily detectable in MCF-7 cells.

PA1-4398 immunizing peptide corresponds to amino acid residues 532-550 of human NABC1.

Target Information

BCAS1 was identified through positional cloning and was found to be overexpressed in most but not all breast cancer cells lines. Little is known about this protein; BCAS1 is cytoplasmically localized and is thought to form homodimers through coiled-coil structures. High levels of BCAS1 mRNA are seen in brain and prostate tissues, with lower amounts observed in colon, intestine and testis. Cells engineered to overexpress BCAS1 did not lose anchorage-dependent growth or increase their rate of growth, suggesting that BCAS1 is not a prototypical oncogene. The BCAS1 gene was also found to be amplified in other carcinomas such as pancreatic carcinoma, suggesting that BCAS1 may play in important role in the control of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.