Thermo Fisher Scientific BCAS1 Polyclonal Antibody
Human BCAS1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 sodium azide를 포함한 액상 형태입니다. 냉장 또는 냉동 보관 가능하며 연구용으로만 사용됩니다.
- 카탈로그번호
- PA14398
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide: D(532) T N S L Q N G D K L Q K R P E K R Q(550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2258969 |
Product Specific Information
PA1-4398 detects NABC1 in human samples.
It has been successfully used in Western blotting procedures. By Western blot, this antibody detects a ~60 kDa protein representing NABC1 in MCF-7 cell lysates. NABC1 can form dimers, which are readily detectable in MCF-7 cells.
The immunizing peptide corresponds to amino acid residues 532–550 of human NABC1.
Target Information
BCAS1 was identified through positional cloning and found to be overexpressed in most but not all breast cancer cell lines. It is cytoplasmically localized and is thought to form homodimers through coiled-coil structures.
High levels of BCAS1 mRNA are seen in brain and prostate tissues, with lower amounts observed in colon, intestine, and testis.
Cells engineered to overexpress BCAS1 did not lose anchorage-dependent growth or increase their rate of growth, suggesting that BCAS1 is not a prototypical oncogene.
The BCAS1 gene was also found to be amplified in other carcinomas such as pancreatic carcinoma, suggesting that BCAS1 may play an important role in the control of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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