Thermo Fisher Scientific Ataxin 2 Polyclonal Antibody
Ataxin 2 단백질 검출용 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC, Flow cytometry에 사용 가능. 인간 및 랫드 반응성. 동결건조 형태로 제공되며, 항원 친화 크로마토그래피로 정제됨. 연구용 전용.
- 카탈로그번호
- PA578845
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 2–5 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | View 1 publication |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human ATX2 (1293–1313aa TTAHFPYMTHPSVQAHHQQQL) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745961 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I–III.
Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I), which are characterized by cerebellar ataxia combined with additional clinical features such as optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy, and dementia.
SCA2 is caused by expansion of a CAG repeat in the coding region of this gene, with longer expansions resulting in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified, but their full-length sequences have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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