Thermo Fisher Scientific Ataxin 3 Polyclonal Antibody
Human, Mouse, Rat 반응성의 Rabbit Polyclonal Ataxin 3 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합. 항원 친화 크로마토그래피로 정제된 동결건조 형태이며, PBS + trehalose 버퍼에 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Ataxin 3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to human Ataxin 3 (226–254aa, EEDLQRALALSRQEIDMEDEEADLRRAIQ) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745964 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder caused by expansion of (CAG)n repeats in the Ataxin-3 coding region from normal 13–36 to 68–79. The MJD protein interacts with transcription regulators (CBP, p300, PCAF), represses transcription, and acts as a histone-binding deubiquitinating enzyme. There is a negative correlation between age of onset and CAG repeat number.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA5-78848_Ataxin_3_P54252-2_Rabbit.svg, PA5-78848_Ataxin_3_P54252-2_Rabbit_PDP.jpeg)
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