Thermo Fisher Scientific SAP (SLAM-Associated Protein) Monoclonal Antibody (XLP-1D12), PE, eBioscience
인간 SLAM-Associated Protein(SAP)을 인식하는 XLP-1D12 단클론 항체로, PE 형광 표지되어 있습니다. Flow Cytometry용으로 최적화되어 있으며, 4°C 암소 보관. XLP 증후군 및 면역학 연구에 활용 가능.
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Thermo Fisher Scientific SAP (SLAM-Associated Protein) Monoclonal Antibody (XLP-1D12), PE, eBioscience™
Applications
- Intracellular staining
- Flow Cytometry
Tested Dilution
- 5 µL (0.5 µg)/test
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | XLP-1D12 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Wet ice |
| RRID | AB_2572731 |
Product Specific Information
The monoclonal antibody XLP-1D12 reacts with human SLAM-associated protein (SAP, also known as SH2D1A). SAP is a 15-kDa SH2 domain-containing adaptor protein. Upon CD150/SLAM receptor ligation, SAP recruits Fyn tyrosine kinase to activate downstream signaling. It is expressed in thymocytes, T cells, NK cells, and NKT cells.
SAP plays roles in follicular T helper cell differentiation, NKT cell development, Th1/Th2 differentiation, and regulation of NK and CD8+ T cell cytotoxicity. Mutations in SAP cause X-linked lymphoproliferative (XLP) syndrome, associated with impaired humoral immunity and susceptibility to Epstein-Barr virus and lymphoma. SAP is also linked to autoimmune diseases such as systemic lupus erythematosus.
Applications Reported: Suitable for intracellular staining followed by flow cytometric analysis.
Applications Tested: Pre-titrated and validated for intracellular staining using the Foxp3/Transcription Factor Staining Buffer Set (Product #00-5523-00) and BestProtocols® Protocol B.
Use at 5 µL (0.5 µg) per test (100 µL final volume). Typical cell range: 10⁵–10⁸ cells/test.
Excitation/Emission: 488–561 nm / 578 nm
Laser Compatibility: Blue, Green, Yellow-Green lasers
Filtration: 0.2 µm post-manufacturing filtered
Target Information
This gene encodes a protein involved in bidirectional stimulation of T and B cells. It contains an SH2 domain and associates with signaling lymphocyte-activation molecules, modulating SHP-2 recruitment and signal transduction. Mutations cause X-linked lymphoproliferative syndrome (Duncan disease), characterized by susceptibility to Epstein-Barr virus infection, severe mononucleosis, and malignant lymphoma. Multiple transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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