Thermo Fisher Scientific CXCR4 Monoclonal Antibody (12G5)
CXCR4 단백질을 인식하는 Mouse IgG2a 단클론 항체로, IHC(F/P) 및 Flow Cytometry에 사용 가능. HIV-1/2 연구 및 면역학 연구에 활용. 비결합형 액상 형태로 -20°C에서 보관.
✨AI 추천 연관 상품
AI가 분석한 이 상품과 연관된 추천 상품들을 확인해보세요
연관 상품을 찾고 있습니다...
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 3 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | View publications |
| Flow Cytometry (Flow) | Assay-dependent | View publications |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Detail |
|---|---|
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12G5 |
| Immunogen | SIV-infected SupT1 cells injected into Balb/c mice |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Wet or Dry ice (international) |
| RRID | AB_2536355 |
Additional Formats
Target Information
CXCR4 (also known as Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains. It functions as a co-receptor for X4 HIV-1 entry into CD4+ cells and also serves as a co-receptor for HIV-2 binding through envelope glycoprotein gp120. CXCR4 mediates signal transduction via CXCL12/SDF-1 binding, leading to increased intracellular calcium and MAPK1/MAPK3 activation.
CXCR4 plays essential roles in:
- Hematopoiesis and cardiac ventricular septum formation
- Gastrointestinal vascularization via endothelial remodeling
- Neuronal survival in the hippocampus and cerebellar development
- Mediating LPS-induced inflammatory responses, including TNF secretion
Antibodies to CXCR4 can block HIV-1 and HIV-2 fusion and infection in human target cells. The amino-terminal domain and second extracellular loop of CXCR4 serve as HIV binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
🏷️Thermo Fisher Scientific 상품 둘러보기
동일 브랜드의 다른 상품들을 확인해보세요
Thermo Fisher Scientific
Thermo Fisher Scientific TNFR1 Monoclonal Antibody (943BC51G1)
632,500원
Thermo Fisher Scientific
Thermo Fisher Scientific TNFR1 Monoclonal Antibody (943BC15C12), Biotin
632,500원
Thermo Fisher Scientific
Thermo Fisher Scientific CXCR4 Monoclonal Antibody (12G5)
751,000원
Thermo Fisher Scientific
Thermo Fisher Scientific CD181 (CXCR1) Monoclonal Antibody (501)
767,100원
Thermo Fisher Scientific
Thermo Fisher Scientific TNFR2 (soluble) Monoclonal Antibody (897C2G9)
645,200원
배송/결제/교환/반품 안내
배송 정보
| 기본 배송비 |
| 교환/반품 배송비 |
|
|---|---|---|---|
| 착불 배송비 |
| ||
| 교환/반품 배송비 |
| ||
결제 및 환불 안내
| 결제수단 |
|
|---|---|
| 취소 |
|
| 반품 |
|
| 환급 |
|
교환 및 반품 접수
| 교환 및 반품 접수 기한 |
|
|---|---|
| 교환 및 반품 접수가 가능한 경우 |
|
| 교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
| 교환 절차 |
|
|---|---|
| 반품 절차 |
|