Thermo Fisher Scientific CXCR4 Monoclonal Antibody (12G5)
CXCR4 단백질을 인식하는 Mouse IgG2a 단클론 항체로, IHC(F/P) 및 Flow Cytometry에 사용 가능. HIV-1/2 연구 및 면역학 연구에 활용. 비결합형 액상 형태로 -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 3 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | View publications |
| Flow Cytometry (Flow) | Assay-dependent | View publications |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Detail |
|---|---|
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12G5 |
| Immunogen | SIV-infected SupT1 cells injected into Balb/c mice |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Wet or Dry ice (international) |
| RRID | AB_2536355 |
Additional Formats
Target Information
CXCR4 (also known as Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains. It functions as a co-receptor for X4 HIV-1 entry into CD4+ cells and also serves as a co-receptor for HIV-2 binding through envelope glycoprotein gp120. CXCR4 mediates signal transduction via CXCL12/SDF-1 binding, leading to increased intracellular calcium and MAPK1/MAPK3 activation.
CXCR4 plays essential roles in:
- Hematopoiesis and cardiac ventricular septum formation
- Gastrointestinal vascularization via endothelial remodeling
- Neuronal survival in the hippocampus and cerebellar development
- Mediating LPS-induced inflammatory responses, including TNF secretion
Antibodies to CXCR4 can block HIV-1 and HIV-2 fusion and infection in human target cells. The amino-terminal domain and second extracellular loop of CXCR4 serve as HIV binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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