Thermo Fisher Scientific TNFR1 Monoclonal Antibody (943BC15C12), Biotin
인간 TNFR1 단백질을 인식하는 마우스 단클론 항체로, Biotin으로 표지되어 있습니다. ELISA 등 샌드위치 분석에서 검출 항체로 사용 권장됩니다. Protein A로 정제되었으며, PBS 완충액에 BSA와 sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 943BC15C12 |
| Immunogen | Recombinant human sTNF-RI |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.5, with 5 mg/mL BSA |
| Contains | 0.5 mg/mL sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536358 |
Product Specific Information
This product is recommended as a detection antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 943BC15C12 2D6.
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors. TNFR1 plays an important role in cytokine-mediated signaling, positive regulation of the NF-κB pathway, angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 is released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12.
Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1 to regulate signal transduction. Germline mutations in TNFR1’s extracellular domain are associated with autosomal dominant periodic fever syndrome, linked to impaired receptor clearance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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