Thermo Fisher Scientific TNFR1 Monoclonal Antibody (943BC51G1)
인간 TNFR1 단백질을 인식하는 Mouse IgG1 단일클론 항체입니다. Sandwich ELISA의 capture antibody로 권장됩니다. 단백질 A로 정제되었으며 PBS(pH 7.4) 용액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 943BC51G1 |
| Immunogen | Recombinant human sTNF-RI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.5 mg/mL sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536359 |
Product Specific Information
This product is recommended as a capture antibody in Sandwich ELISA applications.
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors. TNFR1 plays an important role in cytokine-mediated signaling, positive regulation of the NF-κB pathway, angiogenesis, and regulation of gene expression. The extracellular domain of TNFR1 is released into the circulatory system as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12. Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1 and regulate its signal transduction. Germline mutations in the extracellular domain of TNFR1 are associated with autosomal dominant periodic fever syndrome, and impaired receptor clearance is thought to contribute to the disease mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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