Thermo Fisher Scientific TAGAP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

TAGAP (T-cell activation Rho GTPase-activating protein) is a 731 amino acid protein containing one Rho-GAP domain and exists as four alternatively spliced isoforms. TAGAP may function as a GTPase-activating protein and play important roles during T-cell activation.
The TAGAP gene spans approximately 10,685 bases and maps to human chromosome 6q25.3. Chromosome 6, comprising about 6% of the human genome, contains ~1,200 genes within 170 million base pairs. Deletion of part of the q arm of chromosome 6 is linked to early-onset intestinal cancer, suggesting a cancer susceptibility locus.
Chromosome 6 is also associated with various diseases, including porphyria cutanea tarda (via the HFE gene), Parkinson’s disease (PARK2 gene), and several metabolic and genetic disorders such as Stickler syndrome, hydroxylase deficiency, and maple syrup urine disease. A bipolar disorder susceptibility locus has also been identified on the q arm of chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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