Thermo Fisher Scientific PRPF40A Polyclonal Antibody
PRPF40A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%)를 가지며 연구용으로 사용됩니다.
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Applications
- Western Blot (WB): 1:500–1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 466–511 of Human PRPF40A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719666 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is >95% (by SDS-PAGE).
Target Information
FNBP3 (Formin-binding protein 3) is a 957 amino acid protein encoded by the human gene PRPF40A. It belongs to the PRPF40 family and contains five FF domains and two WW domains. These nuclear proteins, harboring both WW and FF interaction modules, bind to splicing factors and RNA polymerase II, potentially linking transcription with splicing.
Through its WW domains, FNBP3 binds to the Formin proline-rich regions. Also known as Pre-mRNA-processing factor 40 homolog A, FNBP3 binds to the WASL/N-WASP complex and suppresses its translocation from nucleus to cytoplasm, thereby inhibiting cytoplasmic function. FNBP3 is widely expressed in most tissues and localized to nuclear speckles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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