Thermo Fisher Scientific Phospho-GAB1 (Tyr627) Monoclonal Antibody (T.921.2)
Phospho-GAB1 (Tyr627) 단백질을 특이적으로 인식하는 rabbit monoclonal antibody입니다. Western blot에 적합하며, 인간 시료에서 검증되었습니다. 세포 성장, 분화, 신호전달 연구에 활용 가능합니다.
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Applications
Tested Application
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T.921.2 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding Tyr627 of human Gab1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 20 µg/mL |
| Purification | Purified |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985082 |
Product Specific Information
- MA5-14812 detects Phospho-GAB1 pTyr627 in human samples.
- Predicted to react with mouse and rat based on sequence homology.
- Successfully used in Western blot applications.
- The immunogen is a synthetic phosphopeptide corresponding to residues surrounding Tyr627 of human Gab1.
- Detects Phospho-Gab1 (Tyr627) with a predicted molecular weight of approximately 110 kDa.
Target Information
Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation, and apoptosis.
It can be phosphorylated by multiple receptor tyrosine kinases (RTKs), including:
- Insulin receptor (IR)
- Platelet-derived growth factor receptor beta (PDGFRβ)
- Hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met)
- Epidermal growth factor receptor (EGF)
Gab1 is tyrosine phosphorylated on at least 16 sites, serving as binding sites for PI3K, Grb2, PLCγ1, Nck, and SHP2.
Phosphorylation at Tyr627 and Tyr659 is critical for SHP2 binding and activation of the ERK/MAPK pathway in response to EGF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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