Thermo Fisher Scientific TLR1 Monoclonal Antibody (GD2.F4)

Applications and Tested Dilution

Product Specifications

Additional Formats:

• FITC Conjugate
• Request Custom Conjugation

Product Specific Information

MA1-40167 detects TLR1 from human samples.
The MA1-40167 immunogen is human TLR1.
Positive control: HeLa cells transfected with TLR1 mRNA
Negative control: Mock transfected HeLa cells

Target Information

TLR1 protein is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity.
TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate cytokine production necessary for effective immunity.

In mammals, TLRs are transmembrane proteins characterized by multiple leucine-rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain.
TLR1 interacts with TLR2 in mice, enhancing NF-κB activation in response to synthetic lipopeptides. They recognize lipid configurations of native mycobacterial lipoproteins and several tri-acylated lipopeptides.
Different transcript lengths may result from alternative polyadenylation or splicing events in the TLR1 gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.