Thermo Fisher Scientific TLR1 Monoclonal Antibody (GD2.F4), Biotin

Applications and Tested Dilutions

Product Specifications

Additional Formats

• FITC
• Request custom conjugation

Product Specific Information

MA1-40169 detects TLR1 from human samples.
It has been successfully used in flow cytometry applications.
The immunogen is human TLR1.

Controls:

• Positive control: HeLa cells transfected with TLR1 mRNA
• Negative control: Mock transfected HeLa cells

Target Information

TLR1 protein is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity.
TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate cytokine production necessary for effective immunity.

The mammalian TLR family comprises transmembrane proteins characterized by multiple leucine-rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain.
In mice, TLR1 interacts with TLR2, and co-expression enhances NF-kappaB activation in response to synthetic lipopeptides.
TLR1 recognizes the lipid configuration of native mycobacterial lipoproteins and several tri-acylated lipopeptides.
Different transcript lengths may result from alternative polyadenylation or splicing of the TLR1 gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.