Thermo Fisher Scientific MFN2 Monoclonal Antibody (N153/5)
MFN2 단백질 검출용 마우스 단클론 항체로, Western blot, IHC, ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 단백질 G 정제, PBS/glycerol buffer 보존. 미토콘드리아 융합 연구 및 신경 질환 관련 연구에 활용 가능.
- 카탈로그번호
- MA527647
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N153/5 |
| Immunogen | Fusion protein amino acids 370–600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 aa identical). Human: 92% identity (214/231 aa identical), ~55% identity with Mitofusin-1. |
| Conjugate | Unconjugated |
| Available Conjugates | APC, FITC, PE, PerCP, Request custom conjugation |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735272 |
Product Specific Information
- 1 µg/mL of MA5-27647 was sufficient for detection of Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 90 kDa.
- No cross-reactivity against Mitofusin-1.
- This antibody was formerly sold as S153-5.
Target Information
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. It is involved in the regulation of vascular smooth muscle cell proliferation and may play a role in obesity-related pathophysiology.
Mutations cause Charcot-Marie-Tooth disease type 2A2 and hereditary motor and sensory neuropathy VI, both disorders of the peripheral nervous system.
Defects have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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