Thermo Fisher Scientific MFN2 Monoclonal Antibody (N153/5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• 1 µg/mL of MA5-27647 was sufficient for detection of Mitofusin-2 in 20 µg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Detects approximately 90 kDa.
• No cross-reactivity against Mitofusin-1.
• This antibody was formerly sold as S153-5.

Target Information

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. It is involved in the regulation of vascular smooth muscle cell proliferation and may play a role in obesity-related pathophysiology.
Mutations cause Charcot-Marie-Tooth disease type 2A2 and hereditary motor and sensory neuropathy VI, both disorders of the peripheral nervous system.
Defects have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.