Thermo Fisher Scientific p53 Recombinant Rabbit Monoclonal Antibody (SA39-07)

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Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 activation leads to transcription of genes such as p21waf1, regulating G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is crucial for p53 activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays roles in cancer suppression, aging, oxidative stress response, and neuronal function. It is expressed at low levels in normal cells but highly in transformed cell lines. Mutations in TP53 cause loss of tumor suppressor activity and occur in many human cancers, including hereditary cancer syndromes such as Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.