Thermo Fisher Scientific SHH Recombinant Polyclonal Antibody (23HCLC)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies, and providing the consistency achievable only with recombinant technology.
These antibodies recognize multiple epitope sites on the target, offering higher detection sensitivity for low-abundance targets. Because the antibody population is defined and reproducible, lot-to-lot variability common in traditional polyclonal production is eliminated.

Target Information

Sonic Hedgehog (SHH) is expressed during embryogenesis and is essential for early developmental patterning. It serves as a key inductive signal in the formation of the ventral neural tube, anterior-posterior limb axis, and ventral somites.
The SHH protein is produced as a precursor that undergoes autocatalytic cleavage. The N-terminal fragment is soluble and mediates signaling activity, while the C-terminal fragment facilitates precursor processing and attaches a cholesterol moiety to the N-terminal fragment. This modification anchors the signaling domain to the cell surface, preventing unrestricted diffusion in the embryo.
Mutations in SHH or its signaling pathway can cause holoprosencephaly (HPE), characterized by abnormal forebrain and facial development, and may contribute to VACTERL syndrome, which involves vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.