Thermo Fisher Scientific TWIST1 Polyclonal Antibody, MaxPab
TWIST1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. Affinity chromatography로 정제되었으며, PBS(pH 7.4) 용액 상태로 제공됩니다. 인간 시료에 반응하며, -20°C에서 보관 권장됩니다.
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Applications
Tested Applications and Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TWIST1 (NP_000465.1, 1–202 a.a.) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
MMQDVSSSPV SPADDSLSNS EEEPDRQQPP SGKRGGRKRR SSRRSAGGGA GPGGAAGGGV GGGDEPGSPA QGKRGKKSAG CGGGGGAGGG GGSSSGGGSP QSYEELQTQR VMANVRERQR TQSLNEAFAA LRKIIPTLPS DKLSKIQTLK LAARYIDFLY QVLQSDELDS KMASCSYVAH ERLSYAFSVW RMEGAWSMSA SH
Target Information
TWIST1 acts as a transcriptional regulator. It inhibits myogenesis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction.
TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. It regulates cranial suture patterning and fusion and gene expression depending on dimer composition.
Mutations in the gene are implicated in Saethre-Chotzen syndrome, characterized by cranial and facial abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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