Thermo Fisher Scientific KCNQ4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitution:
  Reconstitute with 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
  Ships as lyophilized powder at room temperature.
  Upon arrival, store at -20°C.
  Reconstituted solution can be stored at 4°C for up to 1 week.
  For longer storage, aliquot and store at -20°C.
  Avoid multiple freeze/thaw cycles.
  Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The KCNQ4 gene encodes a potassium channel protein involved in regulating neuronal excitability, particularly in cochlear sensory cells. This channel’s current is inhibited by M1 muscarinic acetylcholine receptors and activated by the anticonvulsant drug retigabine. KCNQ4 can form homomultimeric or heteromultimeric channels (with KCNQ3). Mutations in this gene cause nonsyndromic sensorineural deafness type 2, an autosomal dominant progressive hearing loss. Two transcript variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.