Thermo Fisher Scientific FGFR1 Recombinant Rabbit Monoclonal Antibody (7W2J1)
FGFR1 단백질을 인식하는 토끼 단클론 항체로, Western blot, IHC, ICC/IF, ELISA에 적합합니다. HEK293 세포에서 발현된 재조합 항체이며, 고순도의 친화 크로마토그래피 정제 제품입니다. 인간, 마우스, 랫트 시료에 반응하며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7W2J1 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 600–700 of human FGFR1 (NP_075598.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094175 |
Product Specific Information
Immunogen sequence:
LVSCAYQVAR GMEYLASKKC IHRDLAARNV LVTEDNVMKI ADFGLARDIH HIDYYKKTTN GRLPVKWMAP EALFDRIYTH QSDVWSFGVL LWEIFTLGGS P
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases serving as high-affinity receptors for 17 growth factors (FGF1–17). The FGF Receptor family plays a crucial role in biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone growth.
FGFR1 undergoes alternative splicing, generating multiple variants expressed during embryonic development and in adult tissues. Mutations or aberrations in FGFR1 are associated with diseases including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome. Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorders and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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