Thermo Fisher Scientific SLFN11 Recombinant Rabbit Monoclonal Antibody (8G3G0)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

8G3G0

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 132-328 of human SLFN11 (NP_689483.3). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SLFN11,uniProtId:Q7Z7L1-1,ncbiNodeId:9606,antigenRange:132-328,antigenLength:901,antigenImageFileName:MA5-51227_SLFN11_Q7Z7L1-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51227_SLFN11_Q7Z7L1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3093124

Product Specific Information

Immunogen sequence: LYRRSETSVR SMDSREAFCF LKTKRKPKIL EEGPFHKIHK GVYQELPNSD PADPNSDPAD LIFQKDYLEY GEILPFPESQ LVEFKQFSTK HFQEYVKRTI PEYVPAFANT GGGYLFIGVD DKSREVLGCA KENVDPDSLR RKIEQAIYKL PCVHFCQPQR PITFTLKIVN VLKRGELYGY ACMIRVNPFC CAVFSEA

Target Information

Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.