Thermo Fisher Scientific AMPD1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human AMPD1, validated for WB and IHC(P) applications. Reacts with multiple species including human and mouse. High-purity antigen affinity–purified liquid form, suitable for research use only.
- 카탈로그번호
- PA523172
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Marsupial, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 140–190 of human AMPDA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540698 |
Target Information
AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes a central reaction in purine nucleotide biosynthesis where AMP is deaminated to IMP, liberating ammonia.
There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle–specific isoform located in type II muscle fibers, neuromuscular junctions, and capillaries.
This protein serves as a sensor for cellular energy requirements. AMPD1 deficiency leads to irregular muscle metabolism due to reduced ATP degradation, phosphocreatine hydrolysis, and lactic acid accumulation.
Mutations in AMPD1 have been associated with neuromuscular disorders, exercise-induced skeletal muscle myopathies, and congestive heart failure related to coronary artery disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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